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A recent United States Census Bureau report reveals that the United States ranks 8th in the world, and 1st in the United States, in youth tobacco use. (See “Youth Smoking Rates Highest in the World” by the United States Census Bureau, Government Printing Office, February 2005). The United States youth smoking rate is highest among the G8 countries (United Kingdom, United States, Canada, Germany, France, Italy, Japan, and Russia), and in the twenty-five leading countries (Argentina, Australia, Brazil, China, Egypt, Greece, Hungary, India, Indonesia, Ireland, Mexico, Netherlands, New Zealand, Poland, Portugal, Republic of Korea, Spain, United Kingdom, United States, Uruguay, and Venezuela). Among all the G8 countries, the United States is second only to Russia in its youth smoking rate. As early as 1977, the United States was listed as number one in youth smoking by the Surgeon General of the United States of America. (See U.S. Surgeon General, “Report of the Surgeon General on the Health Consequences of Smoking,” US Department of Health and Human Services, Public Health Service, 1977). Attempts to address this issue have included the creation of various smoke-free air policies, such as increasing the age at which smoking is prohibited in public places. However, these policies fail to address the issue of nicotine use. For example, merely age restrictions do not address the use of e-cigarettes (e.g., “smokeless” cigarettes, cigarillos, and hookah), as e-cigarettes are not subject to legal age restrictions. Therefore, the attempt to curb the amount of nicotine used among youth by adopting an age-restrictive policy has been ineffective. Thus, there is a need in the art for other solutions to address the nicotine use among youth.Autoantibodies to integrins: specific clinical features of primary systemic vasculitis. The mechanisms of autoimmunity in systemic vasculitis (SV) are only partially understood. Autoantibodies directed against integrins, the main adhesion receptors of the immune system, are found in sera of patients with SV. The specific clinical, laboratory, and therapeutic features of SV patients with these autoantibodies are described. Anti-integrin autoantibodies were assessed in 182 patients with biopsy-proven SV (93 systemic lupus erythematosus [S





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